Sebastian Seung Biography

Neurons in the brain are linked together in a confusing system. The connectome is the whole network of connections between brain neurons; think of it as the brain's wiring diagram. Sebastian Seung and his team at MIT are developing new techniques for identifying and visualizing the connectome. Even though we receive our whole genome upon birth, memories are not stored in the genome; instead, they are acquired throughout life and amassed in the mind. According to Seung's theory, memories and experiences are stored in the connections between neurons because we are our connectome. Seung and his colleagues, Winfried Denk at the Max Planck Institute and Jeff Lichtman at Harvard University, are working on a method to thin-cut a brain (likely starting with a mouse brain) and follow each neural pathway from cut to cut, revealing the brain's wiring diagram and providing an incredibly improved way to imagine how the brain works. They are not the first to do anything similar; in fact, Sydney Brenner received the Nobel Prize for her work on organizing all 7000 relationships in the sensory system of the tiny worm C. elegans. In any event, the worm only had 302 nerve cells after twelve years of labor on the part of his crew. One of Seung's accomplishments is his use of advanced imagining and AI to process the enormous amount of data that a mouse brain would produce and turn it into beautiful visual guides that depict the pathways of thinking and feeling.

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