Claudia O'Doherty is originally an Australian standup comedian, who has won awards including the 2009 Melbourne Fringe Best Comedy Award and the Brisbane Comedy Festival Award for her debut show Monsters of the Deep 3D. O'Doherty is also a published author, having co-written 100 Facts About Pandas with David O'Doherty and Mike Ahern. She is also an Actor, currently appearing in Love, and also a Comedy Writer.

O'Doherty's father is Mental as Anything band member and acclaimed artist, Reg Mombassa (Chris O'Doherty).

O'Doherty has appeared on Scott Aukerman's comedy podcast Comedy Bang! Bang! alongside "Weird Al" Yankovic, Jimmy Pardo, Nick Kroll, Stars, and Peaches, among others. She has also appeared on the TV series Comedy Bang! Bang! alongside Lil Jon.

O'Doherty has appeared on the television show Problems, and in Judd Apatow's film Trainwreck, opposite Bill Hader and Amy Schumer. In 2014, O'Doherty appeared in The Inbetweeners 2 as an airline rep. In January 2015, she appeared on the British panel show QI alongside Jimmy Carr, Suggs, regular panellist Alan Davies and host Stephen Fry. In addition to appearing in an episode of Inside_Amy_Schumer in 2015 O'Doherty is also a writer for the show and will be appearing on future episodes. Schumer discovered her after Hader sent Schumer links to O'Doherty's Webisodes, which were made for Channel_4 in the UK.

Starting in 2016, O'Doherty appears in the Netflix series Love. She plays the role of Bertie, the new roommate of Mickey, played by Gillian Jacobs, one of the stars of the series along with Paul Rust, who is also one of the creators of the series.