Dr. Rudolf Jaenisch Biography

Jaenisch has focused on creating transgenic mice that enable his lab to study forms of cancer and neurological diseases that have long baffled researchers.
Jaenisch's first breakthrough occurred in the 1970s when he demonstrated for the first time that foreign DNA could be integrated into the DNA of early mouse embryos; mice derived from these embryos carried the foreign genes in all of their tissues. Subsequently Jaenisch injected retrovirus into early mouse embryos and showed that leukemia DNA sequences had integrated not only into the mouse genome but also to its offspring. These mice were the first transgenic animals in history.
Jaenisch also is a leader in the field of therapeutic cloning also called nuclear transfer in which the genetic information from one cell is transplanted into an unfertilized egg from which DNA has been removed. When placed in a Petri dish this egg develops into a blastocyst from which stem cells can be taken. Jaenisch's therapeutic cloning research occurs exclusively with mice but he advocates using the same techniques with human cells in order to advance embryonic stem cell research. Conversely Jaenisch opposes human reproductive cloning in which the egg is placed not in a Petri dish but into the uterus of a female in the hope that it will develop into a fetus.

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